Yeah try not to give up, I had some major roadblocks early on. I pretty much ruined the first two batches of material I'd tried and just about quit. I'd tried Aluminite first and then Tap products and neither worked well for me.
Fortunately I am really stubborn and decided to give it one more go and managed to get thinge worked out using Mirco-Mark and later Smooth-On.
The point is it's not easy getting started and you make all sorts of mistakes early on. Once you get some sucesses it'll be a whole new world and feel so much more rewarding.
The big projects are really tough for first time stuff, I was doing small stuff but having done some bigger stuff since then I imagine that I would have been ready to tear my hair out had those been my first casting attempts. Maybe take a short break to recharge your energies and give it another go with something smaller just to get the feel down. It like riding a skate board, it's a total pain at first and even when you are good at it you fall down periodically.
(where with a bike you tend not to mess up on)
I still make lots of bone headed mistakes, tonight I just ruined a brand new mold because I forgot to add B side to the resin and dumped the raw A side in, which binds with the silicone if not taken off right away. oops.
With practice you tend to make less mistakes, but they still happen and you gotta stay posative.
As far as the pressure levels, none of my pots have ever held pressure for much longer than 1-2 hours. But that's ok as long as the pressure drop is fairly slow. Squeezing out the excess air bubbles is the main focus of pressurizing and that is actually completed within a few minutes. If the proper pressure level is reached if can slowly taper off and the molds shouldn't have any issues.
If you use the lego blocks for your walls and it returns to normal room pressure too quickly air can seep back into the mold along the lego faces. But this shouldn't occur if it's just a regular box made from solid plastic. (The legos trap air internally) I went and drilled exit holes along the outside of my legos that way the air exiting goes out that way rather than into the silicone should it depressurize suddenly.
Typically I only leave my molds under pressure for about an hour as my pot has leaked down to 2-5 PSI by then. I then set the mold on a level counter for several hours while it finishes curing. My compressor doesn't maintain pressure very consistantly and tends to blow the safetly valve if let unattended. Fortunately I just fill it initally and then let it slow leak and there's no issues.
Also if you are using the standard 2.5 gallon paint pots that most of us use it'll hold 60PSI no problem, you just have to buy a higher rated relief valve capable of 70-80PSI. I bought mine off ebay for about $7. I was really freaked out about taking it that high at first but it's held just fine.
I know that some materials witha sulfer content will mess with various plastics and styrene, haven't run into resin doing that but I've had a pack of clay make my legos all gooey and wreck styrene master. I've bought stuff labeled as sulfer free since then and not had a repeat of that.
There's times where learning how to cast feels like you are smashing your head against the wall, but it does get better.